A Strategy for the Risk Assessment of Human Genotoxic Metabolites-Reference-Cited by-同舟云学术

A Strategy for the Risk Assessment of Human Genotoxic Metabolites

Published:2009-01-27 Issue:2 Volume:22 Page:348-356
ISSN:0893-228X
Container-title:Chemical Research in Toxicology
language:en
Short-container-title:Chem. Res. Toxicol.

Author:

Dobo Krista L.¹,Obach R. Scott¹,Luffer-Atlas Debra¹,Bercu Joel P.¹

Affiliation:

1. Pfizer Global Research and Development, Drug Safety Research and Development, Genetic Toxicology, Groton, Connecticut, Pfizer Global Research and Development, Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, Groton, Connecticut, Lilly Research Laboratories, Drug Disposition, Indianapolis, Indiana, and Lilly Research Laboratories, Health Safety and Environmental, Indianapolis, Indiana

Publisher

American Chemical Society (ACS)

Subject

Toxicology,General Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/tx8004339

Reference38 articles.

1. Strategy for genotoxicity testing—Metabolic considerations

2. Drug Metabolites in Safety Testing

3. United States Food and Drug Administration: Center for Drug Evaluation and Research. (2008) Guidance for Industry Safety Testing of Drug Metabolites.http://www.fda.gov/cder/guidance/6897fnl.pdf.

4. SEEING THROUGH THE MIST: ABUNDANCE VERSUS PERCENTAGE. COMMENTARY ON METABOLITES IN SAFETY TESTING

5. Metabolites and Safety: What Are the Concerns, and How Should We Address Them?

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