Synthesis of Potent Cyclic Hexapeptide NK-1 Antagonists. Use of a Minilibrary in Transforming a Peptidal Somatostatin Receptor Ligand into an NK-1 Receptor Ligand via a Polyvalent Peptidomimetic-Reference-Cited by-同舟云学术

Synthesis of Potent Cyclic Hexapeptide NK-1 Antagonists. Use of a Minilibrary in Transforming a Peptidal Somatostatin Receptor Ligand into an NK-1 Receptor Ligand via a Polyvalent Peptidomimetic

Published:1996-01-01 Issue:13 Volume:39 Page:2441-2448
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Hirschmann Ralph¹,Yao Wenqing¹,Cascieri Margaret A.¹,Strader Catherine D.¹,Maechler Laurie¹,Cichy-Knight Maria A.¹,Hynes, John¹,van Rijn Rachel D.¹,Sprengeler Paul A.¹,Smith Amos B.¹

Affiliation:

1. Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, Merck Research Laboratories, Rahway, New Jersey 07065, Schering-Plough Research Institute, Kenilworth, New Jersey 07044, and Panlabs Inc., 11804 North Creek Parkway South, Bothell, Washington 98011

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm960281e

Reference51 articles.

1. On the origins of the DNA sequence selectivity of mitomycin monoalkylation transformations

2. De novo design and synthesis of somatostatin non-peptide peptidomimetics utilizing .beta.-D-glucose as a novel scaffolding

3. Preparation of exo-6-benzyl-exo-2-(m-hydroxyphenyl)-1-dimethylaminomethylbicyclo[2.2.2.]octane. A non-peptide mimic of enkephalins

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