1. Pharmaceutical Development and Manufacturing Sciences, Janssen Pharmaceutica, Turnhoutseweg 30, B-2340 Beerse, Belgium, Department Chemie und Biochemie, Ludwig-Maximilian Universität München, Butenandtstrasse 5-12, Haus F, 81377 München, Germany, and WuxiApptec, Process Chemistry, 288 Fute Zhong road, Shanghai 200131, People’s Republic of China