A Piecewise Design Approach to Engineering a Miniature ACE2 Mimic to Bind SARS-CoV-2

Author:

Vishweshwaraiah Yashavantha L.1,Hnath Brianna12ORCID,Wang Jian1ORCID,Chandler Morgan3ORCID,Mukherjee Arnab45,Yennawar Neela H.6ORCID,Booker Squire J.457ORCID,Afonin Kirill A.3ORCID,Dokholyan Nikolay V.1238ORCID

Affiliation:

1. Department of Pharmacology, Penn State College of Medicine, Hershey, Pennsylvania 17033-0850, United States

2. Department of Biomedical Engineering, Penn State University, University Park, Pennsylvania 16802, United States

3. Department of Chemistry, University of North Carolina at Charlotte, Charlotte, North Carolina 28223, United States

4. Department of Chemistry, Penn State University, University Park, Pennsylvania 16802, United States

5. The Howard Hughes Medical Institute, Penn State University, University Park, Pennsylvania 16802, United States

6. The Huck Institutes of the Life Sciences, Penn State University, University Park, Pennsylvania 16802, United States

7. Department of Biochemistry & Molecular Biology, Penn State University, University Park, Pennsylvania 16802, United States

8. Department of Biochemistry & Molecular Biology, Penn State College of Medicine, Hershey, Pennsylvania 17033-0850, United States

Funder

Penn State College of Medicine

Eberly Foundation

Huck Institutes of the Life Sciences

National Institutes of Health

Passan Foundation

Publisher

American Chemical Society (ACS)

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