Synthesis and Evaluation of a New Generation of Orally Efficacious Benzimidazole-Based Poly(ADP-ribose) Polymerase-1 (PARP-1) Inhibitors as Anticancer Agents-Reference-Cited by-同舟云学术

Synthesis and Evaluation of a New Generation of Orally Efficacious Benzimidazole-Based Poly(ADP-ribose) Polymerase-1 (PARP-1) Inhibitors as Anticancer Agents

Published:2009-10-21 Issue:21 Volume:52 Page:6803-6813
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Tong Yunsong¹,Bouska Jennifer J.¹,Ellis Paul A.¹,Johnson Eric F.¹,Leverson Joel¹,Liu Xuesong¹,Marcotte Patrick A.¹,Olson Amanda M.¹,Osterling Donald J.¹,Przytulinska Magdalena¹,Rodriguez Luis E.¹,Shi Yan¹,Soni Nirupama¹,Stavropoulos Jason¹,Thomas Sheela¹,Donawho Cherrie K.¹,Frost David J.¹,Luo Yan¹,Giranda Vincent L.¹,Penning Thomas D.¹

Affiliation:

1. Cancer Research, Global Pharmaceutical Research and Development, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, Illinois 60064

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm900697r

Reference35 articles.

1. Involvement of poly(ADP-ribose) polymerase in base excision repair

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3. The role of inhibitors of poly(ADP-ribose) polymerase as resistance-modifying agents in cancer therapy

4. Enhanced expression of poly(ADP-ribose) synthetase gene in malignant lymphoma

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