Hypoxia-Selective Antitumor Agents. 12. Nitrobenzyl Quaternary Salts as Bioreductive Prodrugs of the Alkylating Agent Mechlorethamine-Reference-Cited by-同舟云学术

Hypoxia-Selective Antitumor Agents. 12. Nitrobenzyl Quaternary Salts as Bioreductive Prodrugs of the Alkylating Agent Mechlorethamine

Published:1996-01-01 Issue:5 Volume:39 Page:1084-1094
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Tercel Moana¹,Wilson William R.¹,Anderson Robert F.¹,Denny William A.¹

Affiliation:

1. Cancer Research Laboratory and Section of Oncology, Department of Pathology, University of Auckland School of Medicine, Private Bag 92019, Auckland, New Zealand, and Department of Chemistry, University of Auckland, Private Bag 92019, Auckland, New Zealand

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm9507791

Reference51 articles.

1. Oxygen distribution in squamous cell carcinoma metastases and its relationship to outcome of radiation therapy

2. Intratumoral pO2 predicts survival in advanced cancer of the uterine cervix

3. Bioreducible mustards: a paradigm for hypoxia-selective prodrugs of diffusible cytotoxins (HPDCs)

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