Comparison of Large-Scale Routes to Manufacture Chiral exo-2-Norbornyl Thiourea

Author:

Caille Seb1,Boni Jerome1,Cox Geoffrey B.1,Faul Margaret M.1,Franco Pilar1,Khattabi Saab1,Klingensmith Liane M.1,Larrow Jay F.1,Lee James K.1,Martinelli Michael J.1,Miller Larry M.1,Moniz George A.1,Sakai Kenichi1,Tedrow Jason S.1,Hansen Karl B.1

Affiliation:

1. Chemical Process Research and Development, Chemistry Research and Discovery, Amgen Inc., One Amgen Center Drive, Thousand Oaks, California 91320, and 360 Binney Street, Cambridge, Massachusetts 02142, Novasep, Site Eiffel-81, Boulevard de Moselle-BP50, 54340 Pompey, France, Chiral Technologies, 800 North Five Points Road, West Chester, Pennsylvania 19380, and Parc d’Innovation, Gonthier d’Andernach Boulevard, 67400 Illkrich-Cedex, France

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Reference21 articles.

1. Preparative Enantioselective Chromatography

2. Two Asymmetric Syntheses of AMG 221, an Inhibitor of 11β-Hydroxysteroid Dehydrogenase Type 1

3. Henriksson, M.; Homan, E.; Johansson, L.; Vallgarda, J.; Williams, M.; Bercot, E.; Fotsch, C. H.; Li, A.; Cai, G.; Hungate, R. W.; Yuan, C.; Tegley, C.; St. Jean, D.; Han, N.; Huang, Q.; Liu, Q.; Bartberger, M. D.; Moniz, G. A.; Frizzle, M. J.Patent WO 2005116002, 2005.

4. Adipocyte-Specific Glucocorticoid Inactivation Protects Against Diet-Induced Obesity

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