Discovery and Optimization of Pyrimidone Indoline Amide PI3Kβ Inhibitors for the Treatment of Phosphatase and Tensin Homologue (PTEN)-Deficient Cancers-Reference-Cited by-同舟云学术

Discovery and Optimization of Pyrimidone Indoline Amide PI3Kβ Inhibitors for the Treatment of Phosphatase and Tensin Homologue (PTEN)-Deficient Cancers

Published:2014-01-15 Issue:3 Volume:57 Page:903-920
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Certal Victor¹,Carry Jean-Christophe¹,Halley Frank¹,Virone-Oddos Angela¹,Thompson Fabienne¹,Filoche-Rommé Bruno¹,El-Ahmad Youssef¹,Karlsson Andreas¹,Charrier Véronique¹,Delorme Cécile¹,Rak Alexey¹,Abecassis Pierre-Yves¹,Amara Céline¹,Vincent Loïc¹,Bonnevaux Hélène¹,Nicolas Jean-Paul¹,Mathieu Magali¹,Bertrand Thomas¹,Marquette Jean-Pierre¹,Michot Nadine¹,Benard Tsiala¹,Perrin Marc-Antoine¹,Lemaitre Olivier¹,Guerif Stephane¹,Perron Sébastien¹,Monget Sylvie¹,Gruss-Leleu Florence¹,Doerflinger Gilles¹,Guizani Houlfa¹,Brollo Maurice¹,Delbarre Laurence¹,Bertin Luc¹,Richepin Patrick¹,Loyau Véronique¹,Garcia-Echeverria Carlos¹,Lengauer Christoph¹,Schio Laurent¹

Affiliation:

1. Oncology Drug Discovery, §Structure Design Informatics, and Structural Biology, #Drug Disposition and Safety (DSAR), †Protein Production,⊥Pharmaceutical Sciences, ∥Analytical Sciences, Sanofi, 13, quai Jules Guesde, 94403 Vitry-sur-Seine, France

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm401642q

Reference54 articles.

1. The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism

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