An Intramolecular Cyclization Reaction Is Responsible for the in Vivo Inefficacy and Apparent pH Insensitive Hydrolysis Kinetics of Hydrazone Carboxylate Derivatives of Doxorubicin-Reference-Cited by-同舟云学术

An Intramolecular Cyclization Reaction Is Responsible for the in Vivo Inefficacy and Apparent pH Insensitive Hydrolysis Kinetics of Hydrazone Carboxylate Derivatives of Doxorubicin

Published:2006-09-01 Issue:5 Volume:17 Page:1364-1368
ISSN:1043-1802
Container-title:Bioconjugate Chemistry
language:en
Short-container-title:Bioconjugate Chem.

Author:

Lee Cameron C.¹,Cramer Andrew T.¹,Szoka, Francis C.¹,Fréchet Jean M. J.¹

Affiliation:

1. Department of Chemistry, University of California, Berkeley, California 94720-1460, and Department of Pharmaceutical Chemistry, University of California, San Francisco, California 94143-0446

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Pharmaceutical Science,Pharmacology,Biomedical Engineering,Bioengineering,Biotechnology

Link

https://pubs.acs.org/doi/pdf/10.1021/bc060117y

Reference21 articles.

1. Drug-Polymer Conjugates Containing Acid-Cleavable Bonds

2. Polymeric anticancer drugs with pH-controlled activation

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