Matched Molecular Pairs as a Guide in the Optimization of Pharmaceutical Properties; a Study of Aqueous Solubility, Plasma Protein Binding and Oral Exposure-Reference-Cited by-同舟云学术

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Matched Molecular Pairs as a Guide in the Optimization of Pharmaceutical Properties; a Study of Aqueous Solubility, Plasma Protein Binding and Oral Exposure

Published:2006-10-20 Issue:23 Volume:49 Page:6672-6682
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Leach Andrew G.¹,Jones Huw D.¹,Cosgrove David A.¹,Kenny Peter W.¹,Ruston Linette¹,MacFaul Philip¹,Wood J. Matthew¹,Colclough Nicola¹,Law Brian¹

Affiliation:

1. AstraZeneca Pharmaceuticals, Mereside, Alderley Park, Macclesfield SK10 4TG, U.K.

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm0605233

Reference32 articles.

1. Solubility and partitioning I: Solubility of nonelectrolytes in water

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