Novel Approach for Chemotype Hopping Based on Annotated Databases of Chemically Feasible Fragments and a Prospective Case Study: New Melanin Concentrating Hormone Antagonists-Reference-Cited by-同舟云学术

Novel Approach for Chemotype Hopping Based on Annotated Databases of Chemically Feasible Fragments and a Prospective Case Study: New Melanin Concentrating Hormone Antagonists

Published:2009-03-16 Issue:7 Volume:52 Page:2076-2089
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Oyarzabal Julen¹,Howe Trevor¹,Alcazar Jesús¹,Andrés Jose Ignacio¹,Alvarez Rosa M.¹,Dautzenberg Frank¹,Iturrino Laura¹,Martínez Sonia¹,Van der Linden Ilse¹

Affiliation:

1. Departments of Molecular Informatics and Medicinal Chemistry, Johnson & Johnson Pharmaceutical R&D, Jarama 75, 45007 Toledo, Spain, and Department of Molecular Informatics and CNS Biology Department, Johnson & Johnson Pharmaceutical R&D, Turnhoutseweg 30, 2340 Beerse, Belgium

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm8016199

Reference72 articles.

1. On Scaffolds and Hopping in Medicinal Chemistry

2. “Scaffold-Hopping” by Topological Pharmacophore Search: A Contribution to Virtual Screening

3. Scaffold Searching: Automated Identification of Similar Ring Systems for the Design of Combinatorial Libraries

4. CAVEAT: A program to facilitate the design of organic molecules

5. SHOP: Scaffold HOPping by GRID-Based Similarity Searches

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