Aza-peptidyl Michael Acceptors. A New Class of Potent and Selective Inhibitors of Asparaginyl Endopeptidases (Legumains) from Evolutionarily Diverse Pathogens-Reference-Cited by-同舟云学术

Aza-peptidyl Michael Acceptors. A New Class of Potent and Selective Inhibitors of Asparaginyl Endopeptidases (Legumains) from Evolutionarily Diverse Pathogens

Published:2008-04-17 Issue:9 Volume:51 Page:2816-2832
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Götz Marion G.¹,James Karen Ellis¹,Hansell Elizabeth¹,Dvořák Jan¹,Seshaadri Amritha¹,Sojka Daniel¹,Kopáček Petr¹,McKerrow James H.¹,Caffrey Conor R.¹,Powers James C.¹

Affiliation:

1. School of Chemistry and Biochemistry and the Petit Institute for Bioscience and Bioengineering, Georgia Institute of Technology, Atlanta, Georgia 30332-0400, Sandler Center for Basic Research in Parasitic Diseases, Byers Hall, University of California San Francisco, San Francisco, California 94158, Institute of Parasitology, Biology Centre of the Academy of Sciences of the Czech Republic, České Budějovice, CZ-370 05, Czech Republic, and Department of Chemistry, Whitman College, 345 Boyer Avenue, Walla...

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm701311r

Reference54 articles.

1. Identification of the active site of legumain links it to caspases, clostripain and gingipains in a new clan of cysteine endopeptidases

2. Cloning and gene expression of Schistosoma mansoni protease.

3. Cloning and expression of mouse legumain, a lysosomal endopeptidase

4. Identification of Human Asparaginyl Endopeptidase (Legumain) as an Inhibitor of Osteoclast Formation and Bone Resorption

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