Synthesis and Structure–Activity Relationships of Ring-Opened 17-Hydroxywortmannins: Potent Phosphoinositide 3-Kinase Inhibitors with Improved Properties and Anticancer Efficacy-Reference-Cited by-同舟云学术

Synthesis and Structure–Activity Relationships of Ring-Opened 17-Hydroxywortmannins: Potent Phosphoinositide 3-Kinase Inhibitors with Improved Properties and Anticancer Efficacy

Published:2008-02-13 Issue:5 Volume:51 Page:1319-1323
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Zask Arie¹,Kaplan Joshua¹,Toral-Barza Lourdes¹,Hollander Irwin¹,Young Mairead¹,Tischler Mark¹,Gaydos Christine¹,Cinque Michael¹,Lucas Judy¹,Yu Ker¹

Affiliation:

1. Discovery Medicinal Chemistry, Oncology Research, and Chemical Technologies, Wyeth Research, Pearl River, New York 10965

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm7012858

Reference18 articles.

1. The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism

2. Phosphatidylinositol 3-kinase (PI3K) inhibitors as anticancer drugs

3. Structural Determinants of Phosphoinositide 3-Kinase Inhibition by Wortmannin, LY294002, Quercetin, Myricetin, and Staurosporine

4. Studies on the Mechanism of Phosphatidylinositol 3-Kinase Inhibition by Wortmannin and Related Analogs

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