Macromolecular Prodrug That Provides the Irinotecan (CPT-11) Active-Metabolite SN-38 with Ultralong Half-Life, Low Cmax , and Low Glucuronide Formation-Reference-Cited by-同舟云学术

Macromolecular Prodrug That Provides the Irinotecan (CPT-11) Active-Metabolite SN-38 with Ultralong Half-Life, Low Cmax , and Low Glucuronide Formation

Published:2014-03-06 Issue:6 Volume:57 Page:2303-2314
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Santi Daniel V.¹,Schneider Eric L.¹,Ashley Gary W.¹

Affiliation:

1. ProLynx, 455 Mission Bay Boulevard South, Suite 145, San Francisco, California 94158, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm401644v

Reference49 articles.

1. Controlled Release of Proteins from Their Poly(Ethylene Glycol) Conjugates: Drug Delivery Systems Employing 1,6-Elimination

2. Releasable PEGylation of proteins with customized linkers

3. Novel Prodrugs of SN38 Using Multiarm Poly(ethylene glycol) Linkers

4. Novel SN-38–Incorporating Polymeric Micelles, NK012, Eradicate Vascular Endothelial Growth Factor–Secreting Bulky Tumors

5. Synthesis and In Vivo Antitumor Efficacy of PEGylated Poly(l-lysine) Dendrimer−Camptothecin Conjugates

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