Methyl Substitution of a Rexinoid Agonist Improves Potency and Reveals Site of Lipid Toxicity
Author:
Affiliation:
1. Departments of †Chemistry, ‡Biochemistry and Molecular Genetics, §Medicine, and ∥Vision Sciences, University of Alabama at Birmingham, Birmingham, Alabama 35294, United States
Funder
National Institutes of Health
Susan G. Komen for the Cure
Publisher
American Chemical Society (ACS)
Subject
Drug Discovery,Molecular Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/jm5004792
Reference26 articles.
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2. Initial clinical trial of a selective retinoid X receptor ligand, LGD1069.
3. Conformationally Defined Retinoic Acid Analogues. 5. Large-Scale Synthesis and Mammary Cancer Chemopreventive Activity for (2E,4E,6Z,8E)-8- (3‘,4‘-Dihydro-1‘(2‘H)-naphthalen-1‘-ylidene)-3,7-dimethyl-2,4,6-octatrienoic Acid (9cUAB30)
4. Conformationally Defined Retinoic Acid Analogues. 4. Potential New Agents for Acute Promyelocytic and Juvenile Myelomonocytic Leukemias
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