An Approach to Rapid Estimation of Relative Binding Affinities of Enzyme Inhibitors: Application to Peptidomimetic Inhibitors of the Human Immunodeficiency Virus Type 1 Protease-Reference-Cited by-同舟云学术

An Approach to Rapid Estimation of Relative Binding Affinities of Enzyme Inhibitors: Application to Peptidomimetic Inhibitors of the Human Immunodeficiency Virus Type 1 Protease

Published:1996-01-01 Issue:3 Volume:39 Page:705-712
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Viswanadhan Vellarkad N.¹,Reddy M. Rami¹,Wlodawer Alexander¹,Varney Michael D.¹,Weinstein John N.¹

Affiliation:

1. Laboratory of Molecular Pharmacology, National Cancer Institute, Developmental Therapeutics Program, National Institutes of Health, Bethesda, Maryland 20892, Agouron Pharmaceuticals, Inc., 3565 General Atomics Court, San Diego, California 92121, and Macromolecular Structure Laboratory, National Cancer Institute-Frederick Cancer Research and Development Center, ABL-Basic Research Program, Frederick, Maryland 21702

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm940778t

Reference58 articles.

1. STRUCTURE-BASED INHIBITORS OF HIV-1 PROTEASE

2. Crystal structures of HIV-1 protease-inhibitor complexes

3. Structure-based design of nonpeptide inhibitors specific for the human immunodeficiency virus 1 protease.

4. Inhibition of human immunodeficiency virus 1 protease in vitro: rational design of substrate analogue inhibitors.

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