Amide-Based Prodrugs of Spermidine-Bridged Dinuclear Platinum. Synthesis, DNA Binding, and Biological Activity-Reference-Cited by-同舟云学术

Amide-Based Prodrugs of Spermidine-Bridged Dinuclear Platinum. Synthesis, DNA Binding, and Biological Activity

Published:2008-03-14 Issue:7 Volume:51 Page:2254-2260
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Hegmans Alexander¹,Kasparkova Jana¹,Vrana Oldrich¹,Kelland Lloyd R.¹,Brabec Viktor¹,Farrell Nicholas P.¹

Affiliation:

1. Department of Chemistry, Virginia Commonwealth University, Richmond, Virginia 23284-2006, Institute of Biophysics, Academy of Sciences of the Czech Republic, Kralovopolska 135, CZ-61265 Brno, Czech Republic, and Wolfson Institute for Biomedical Research, University College London, Gower Street, London WC1E 6BT, U.K.

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm070813z

Reference30 articles.

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3. Farrell, N., Qu, Y., Bierbach, U., Valsecchi, M., and Menta, E.In30 Years of Cisplatin. Chemistry and Biochemistry of a Leading Anticancer Drug;Lippert, B., Ed.Verlag:Berlin, 1999; pp479–496.

4. Farrell, N.InPolynuclear Platinum Drugs. Metal Ions in Biological Systems;Sigel, A. and Sigel, H., Eds.Marcel Dekker, Inc.:New York, 2004; Vol.41, pp252–296.

5. Novel Approaches to Polynuclear Platinum Pro-Drugs. Selective Release of Cytotoxic Platinum−Spermidine Species through Hydrolytic Cleavage of Carbamates

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