O6-Pyridyloxobutylguanine Adducts Contribute to the Mutagenic Properties of Pyridyloxobutylating Agents

Author:

Mijal Renée S.1,Loktionova Natalia A.1,Vu Choua C.1,Pegg Anthony E.1,Peterson Lisa A.1

Affiliation:

1. Division of Environmental Health Sciences and The Cancer Center, University of Minnesota, Minneapolis, Minnesota 55455, and Department of Cellular and Molecular Physiology, Milton S. Hershey Medical Center, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033

Publisher

American Chemical Society (ACS)

Subject

Toxicology,General Medicine

Reference54 articles.

1. Staretz, M. E., Foiles, P. G., Miglietta, L. M., and Hecht, S. S. (1997) Evidence for an important role of DNA pyridyloxobutylation in rat lung carcinogenesis by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone:  effects of dose and phenethyl isothiocyanate.Cancer Res.57, 259−266.

2. Peterson, L. A., Thomson, N. M., Crankshaw, D. L., Donaldson, E. E., and Kenney, P. J. (2001) Interactions between methylating and pyridyloxobutylating agents in A/J mouse lungs:  implications for 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis.Cancer Res.61, 5757−5763.

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