Bioreductive Activation of a Series of Indolequinones by Human DT-Diaphorase: Structure−Activity Relationships-Reference-Cited by-同舟云学术

Bioreductive Activation of a Series of Indolequinones by Human DT-Diaphorase: Structure−Activity Relationships

Published:1999-09-21 Issue:20 Volume:42 Page:4071-4080
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Phillips Roger M.¹,Naylor Matthew A.¹,Jaffar Mohammed¹,Doughty Stephen W.¹,Everett Steven A.¹,Breen Anthony G.¹,Choudry Guzanfar A.¹,Stratford Ian J.¹

Affiliation:

1. Clinical Oncology Unit and School of Pharmacy, University of Bradford, Bradford BD7 1DP, U.K., The Gray Laboratory Cancer Research Trust, P.O. Box 100, Mount Vernon Hospital, Northwood, Middlesex HA6 2JR, U.K., and School of Pharmacy, University of Manchester, Oxford Road, Manchester M13 9PL, U.K.

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm991063z

Reference37 articles.

1. A polymorphism in NAD(P)H:quinone oxidoreductase (NQO1): relationship of a homozygous mutation at position 609 of the NQO1 cDNA to NQO1 activity

2. Disruption of the DT Diaphorase (NQO1) Gene in Mice Leads to Increased Menadione Toxicity

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