Synthesis, Chiral Resolution, and Enantiopharmacology of a Potent 2,3-Benzodiazepine Derivative as Noncompetitive AMPA Receptor Antagonist-Reference-Cited by-同舟云学术

Synthesis, Chiral Resolution, and Enantiopharmacology of a Potent 2,3-Benzodiazepine Derivative as Noncompetitive AMPA Receptor Antagonist

Published:2005-12-16 Issue:2 Volume:49 Page:575-581
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Zappalà Maria¹,Postorino Giovanna¹,Micale Nicola¹,Caccamese Salvatore¹,Parrinello Nunziatina¹,Grazioso Giovanni¹,Roda Gabriella¹,Menniti Frank S.¹,De Sarro Giovambattista¹,Grasso Silvana¹

Affiliation:

1. Dipartimento Farmaco-Chimico, Università di Messina, Viale Annunziata, 98168 Messina, Italy, Dipartimento di Scienze Chimiche, Università di Catania, Viale A. Doria 6, 95125 Catania, Italy, Istituto di Chimica Farmaceutica, Università di Milano, Viale Abruzzi 42, 20131 Milano, Italy, Pfizer Global Research and Development, Eastern Point Road, Groton, Connecticut 06340, Dipartimento di Medicina Sperimentale e Clinica, Università di Catanzaro, Via T. Campanella, 88100 Catanzaro, Italy

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm050552y

Reference36 articles.

1. Ligands for Glutamate Receptors: Design and Therapeutic Prospects

2. synthesis and Structure-Activity Relationships of 2,3-Benzodiazepines as AMPA Receptor Antagonists

3. Comparison of anticonvulsive and acute neuroprotective activity of three 2,3-benzodiazepine compounds, GYKI 52466, GYKI 53405, and GYKI 53655

4. A crossover, add-on trial of talampanel in patients with refractory partial seizures

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