Novel Non-Peptide Fibrinogen Receptor Antagonists. 1. Synthesis and Glycoprotein IIb-IIIa Antagonistic Activities of 1,3,4-Trisubstituted 2-Oxopiperazine Derivatives Incorporating Side-Chain Functions of the RGDF Peptide-Reference-Cited by-同舟云学术

Novel Non-Peptide Fibrinogen Receptor Antagonists. 1. Synthesis and Glycoprotein IIb-IIIa Antagonistic Activities of 1,3,4-Trisubstituted 2-Oxopiperazine Derivatives Incorporating Side-Chain Functions of the RGDF Peptide

Published:1998-01-24 Issue:4 Volume:41 Page:489-502
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Sugihara Hirosada¹,Fukushi Hideto¹,Miyawaki Toshio¹,Imai Yumi¹,Terashita Zen-ichi¹,Kawamura Masaki¹,Fujisawa Yukio¹,Kita Shunbun¹

Affiliation:

1. Pharmaceutical Research Division, Takeda Chemical Industries, Ltd., 2-17-85, Jusohonmachi, Yodogawa-ku, Osaka 532-8686, Japan, and Discovery Research Division, Takeda Chemical Industries, Ltd., 10, Wadai, Tsukuba-shi, Ibaraki 300-42471, Japan

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm970235u

Reference46 articles.

1. The tetrapeptide analogue of the cell attachment site of fibronectin inhibits platelet aggregation and fibrinogen binding to activated platelets.

2. The platelet membrane glycoprotein IIb-IIIa complex

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