Computational Redesign of a PETase for Plastic Biodegradation under Ambient Condition by the GRAPE Strategy

Author:

Cui Yinglu1,Chen Yanchun12,Liu Xinyue13,Dong Saijun1,Tian Yu’e1,Qiao Yuxin1,Mitra Ruchira12,Han Jing1ORCID,Li Chunli1,Han Xu4,Liu Weidong4,Chen Quan3,Wei Wangqing5,Wang Xin5,Du Wenbin1ORCID,Tang Shuangyan1ORCID,Xiang Hua1ORCID,Liu Haiyan3,Liang Yong5ORCID,Houk Kendall N.6ORCID,Wu Bian1ORCID

Affiliation:

1. CAS Key Laboratory of Microbial Physiological and Metabolic Engineering, State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101,China

2. University of Chinese Academy of Sciences, Beijing 100049,China

3. School of Life Sciences, Hefei National Laboratory for Physical Sciences at the Microscale, University of Science and Technology of China, Hefei 230052,China

4. Industrial Enzymes National Engineering Laboratory, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin 300308,China

5. State Key Laboratory of Coordination Chemistry, Jiangsu Key Laboratory of Advanced Organic Materials, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023,China

6. Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles 90095, California, United States

Funder

Ministry of Science and Technology of the People's Republic of China

Natural Science Foundation of Beijing Municipality

Chinese Academy of Sciences

National Natural Science Foundation of China

Publisher

American Chemical Society (ACS)

Subject

Catalysis,General Chemistry

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