The Peptide Ligase Activity of Human Legumain Depends on Fold Stabilization and Balanced Substrate Affinities-Reference-Cited by-同舟云学术

The Peptide Ligase Activity of Human Legumain Depends on Fold Stabilization and Balanced Substrate Affinities

Published:2021-09-10 Issue:19 Volume:11 Page:11885-11896
ISSN:2155-5435
Container-title:ACS Catalysis
language:en
Short-container-title:ACS Catal.

Author:

Dall Elfriede¹^ORCID,Stanojlovic Vesna¹^ORCID,Demir Fatih²^ORCID,Briza Peter¹,Dahms Sven O.¹^ORCID,Huesgen Pitter F.²³⁴^ORCID,Cabrele Chiara¹^ORCID,Brandstetter Hans¹^ORCID

Affiliation:

1. Department of Biosciences, University of Salzburg, 5020 Salzburg, Austria

2. Central Institute for Engineering, Electronics and Analytics, ZEA-3, Forschungszentrum Jülich, 52428 Jülich, Germany

3. CECAD, Medical Faculty and University Hospital, University of Cologne, 50931 Cologne, Germany

4. Institute for Biochemistry, Faculty of Mathematics and Natural Sciences, University of Cologne, 50674 Cologne, Germany

Funder

Austrian Science Fund

H2020 European Research Council

Publisher

American Chemical Society (ACS)

Subject

Catalysis,General Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acscatal.1c02057

Reference42 articles.

1. An asparaginyl endopeptidase processes a microbial antigen for class II MHC presentation

2. Distinct Protease Requirements for Antigen Presentation In Vitro and In Vivo

3. The expression of legumain, an asparaginyl endopeptidase that controls antigen processing, is reduced in endotoxin-tolerant monocytes

4. Mechanistic and structural studies on legumain explain its zymogenicity, distinct activation pathways, and regulation

5. Activation of legumain involves proteolytic and conformational events, resulting in a context- and substrate-dependent activity profile

Cited by 15 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Phytocystatin 6 is a context‐dependent, tight‐binding inhibitor of Arabidopsis thaliana legumain isoform β;The Plant Journal;2023-09-09

2. Phytocystatin 6 is a context-dependent, tight-binding inhibitor ofArabidopsis thalianalegumain isoform β;2023-05-22

3. Mutations in α-synuclein, TDP-43 and tau prolong protein half-life through diminished degradation by lysosomal proteases;Molecular Neurodegeneration;2023-05-02

4. On the design of a constitutively active peptide asparaginyl ligase for facile protein conjugation;FEBS Open Bio;2023-03-28

5. Substrate‐binding glycine residues are major determinants for hydrolase and ligase activity of plant legumains;New Phytologist;2023-03-14