Elucidating the Catalytic Reaction Mechanism of Orotate Phosphoribosyltransferase by Means of X-ray Crystallography and Computational Simulations-Reference-Cited by-同舟云学术

Elucidating the Catalytic Reaction Mechanism of Orotate Phosphoribosyltransferase by Means of X-ray Crystallography and Computational Simulations

Published:2020-01-02 Issue:3 Volume:10 Page:1871-1885
ISSN:2155-5435
Container-title:ACS Catalysis
language:en
Short-container-title:ACS Catal.

Author:

Roca Maite¹^ORCID,Navas-Yuste Sergio²,Zinovjev Kirill³,López-Estepa Miguel²,Gómez Sara²,Fernández Francisco J.²^ORCID,Vega M. Cristina²^ORCID,Tuñón Iñaki⁴^ORCID

Affiliation:

1. Departament de Química Física i Analítica, Universitat Jaume I, 12071 Castelló, Spain

2. Structural and Chemical Biology, Center for Biological Research (CIB-CSIC), 28040 Madrid, Spain

3. School of Biochemistry, University of Bristol, Bristol BS8 1TD, U.K.

4. Departament de Química Física, Universitat de València, 46100 Burjassot, Spain

Funder

Generalitat Valenciana

Consejo Superior de Investigaciones Científicas

Ministerio de Ciencia, Innovación y Universidades

Universitat Jaume I

Universidad Complutense de Madrid

European Regional Development Fund

Secretaría de Estado de Investigación, Desarrollo e Innovación

Publisher

American Chemical Society (ACS)

Subject

Catalysis,General Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acscatal.9b05294

Reference61 articles.

1. Structural Features of the Phosphoribosyl-Transferases and Their Relationship to the Human Deficiency Disorders of Purine and Pyrimidine Metabolis

2. Human malaria parasite orotate phosphoribosyltransferase: functional expression, characterization of kinetic reaction mechanism and inhibition profile

3. Molecular, kinetic and thermodynamic characterization of Mycobacterium tuberculosisorotate phosphoribosyltransferase

4. Kinetic mechanism of orotate phosphoribosyltransferase from Salmonella typhimurium

5. Studies of the kinetic mechanism of orotate phosphoribosyltransferase from yeast.

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