Enzymatic Stereodivergent Access to Fluorinated β-Lactam Pharmacophores via Triple-Parameter Engineered Ketoreductases

Author:

Mei Ze-Long1,Li Cong-Cong2,Han Xu2,Tian Yu-Chen1,Li Shuo-Han1,Liu Weidong2ORCID,Qu Ge2ORCID,Reetz Manfred T.23,Sun Zhoutong2ORCID,Ma Jun-An1ORCID,Zhang Fa-Guang1ORCID

Affiliation:

1. Department of Chemistry, Tianjin Key Laboratory of Molecular Optoelectronic Sciences, Frontiers Science Center for Synthetic Biology (Ministry of Education), Tianjin University, Tianjin 300072, P. R. China

2. National Technology Innovation Center of Synthetic Biology, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin 300308, P. R. China

3. Biocatalysis Section, Max-Planck-Institut für Kohlenforschung, Kaiser-Wilhelm-Platz 1, 45470 Mülheim an der Ruhr, Germany

Funder

National Key Research and Development Program of China

Special Project for Research and Development in Key areas of Guangdong Province

National Natural Science Foundation of China

Publisher

American Chemical Society (ACS)

Cited by 2 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Advances in aldo-keto reductases immobilization for biocatalytic synthesis of chiral alcohols;International Journal of Biological Macromolecules;2024-08

2. Hot off the Press;Natural Product Reports;2024

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