Exploring the Identity of the General Base for a DNA Polymerase Catalyzed Reaction Using QM/MM: The Case Study of Human Translesion Synthesis Polymerase η-Reference-Cited by-同舟云学术

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Exploring the Identity of the General Base for a DNA Polymerase Catalyzed Reaction Using QM/MM: The Case Study of Human Translesion Synthesis Polymerase η

Published:2019-01-28 Issue:3 Volume:9 Page:2543-2551
ISSN:2155-5435
Container-title:ACS Catalysis
language:en
Short-container-title:ACS Catal.

Author:

Wilson Katie A.¹^ORCID,Fernandes Pedro A.²,Ramos Maria J.²^ORCID,Wetmore Stacey D.¹^ORCID

Affiliation:

1. Department of Chemistry and Biochemistry, University of Lethbridge, 4401 University Drive West, Lethbridge, Alberta T1K 3M4 Canada

2. UCIBIO, REQUIMTE, Departamento de Química e Bioquímica, Faculdade de Ciências, Universidade do Porto, Rua do Campo Alegre s/n, 4169-007 Porto, Portugal

Funder

European Regional Development Fund

Canada Foundation for Innovation

University of Lethbridge

Natural Sciences and Engineering Research Council of Canada

Funda??o para a Ci?ncia e a Tecnologia

Alberta Innovates - Technology Futures

Publisher

American Chemical Society (ACS)

Subject

Catalysis,General Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acscatal.8b04889

Reference57 articles.

1. Stem cell divisions, somatic mutations, cancer etiology, and cancer prevention

2. DNA polymerase η mutational signatures are found in a variety of different types of cancer

3. DNA polymerases and human disease

4. Error-prone translesion synthesis mediates acquired chemoresistance

5. Targeting the Translesion Synthesis Pathway for the Development of Anti-Cancer Chemotherapeutics

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