Simulation-Guided Engineering Enables a Functional Switch in Selinadiene Synthase toward Hydroxylation
Author:
Affiliation:
1. School of Chemistry, Cardiff University, Main Building, Park Place, Cardiff CF10 3AT, U.K.
2. School of Biochemistry, University of Bristol, University Walk, Bristol BS8 1TD, U.K.
Funder
Biotechnology and Biological Sciences Research Council
Publisher
American Chemical Society (ACS)
Link
https://pubs.acs.org/doi/pdf/10.1021/acscatal.4c02032
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1. Structural and Chemical Biology of Terpenoid Cyclases
2. Functional Characterization of Novel Sesquiterpene Synthases from Indian Sandalwood, Santalum album
3. Terpene Biosynthesis: Modularity Rules
4. Production of Terpenoids by Synthetic Biology Approaches
5. Helenalin Acetate, a Natural Sesquiterpene Lactone with Anti-inflammatory and Anti-cancer Activity, Disrupts the Cooperation of CCAAT Box/Enhancer-binding Protein β (C/EBPβ) and Co-activator p300
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