On the Mechanism and Selectivity of Palladium-Catalyzed C(sp<sup>3</sup>)–H Arylation of Pyrrolidines and Piperidines at Unactivated C4 Positions: Discovery of an Improved Dimethylaminoquinoline Amide Directing Group-Reference-Cited by-同舟云学术

On the Mechanism and Selectivity of Palladium-Catalyzed C(sp³)–H Arylation of Pyrrolidines and Piperidines at Unactivated C4 Positions: Discovery of an Improved Dimethylaminoquinoline Amide Directing Group

Published:2023-07-07 Issue:14 Volume:13 Page:9597-9615
ISSN:2155-5435
Container-title:ACS Catalysis
language:en
Short-container-title:ACS Catal.

Author:

Antermite Daniele¹,White Andrew J. P.¹,Casarrubios Luis¹²^ORCID,Bull James A.¹^ORCID

Affiliation:

1. Department of Chemistry, Molecular Sciences Research Hub, Imperial College London, White City Campus, Wood Lane, London W12 0BZ, U.K.

2. Departamento de Química Organica I, Facultad de Ciencias Químicas, Universidad Complutense and Centro de Innovación en Química Avanzada (ORFEO−CINQA), Madrid 28040, Spain

Funder

Royal Society

Ministerio de Educaci?n y Formaci?n Profesional

Publisher

American Chemical Society (ACS)

Subject

Catalysis,General Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acscatal.3c01980

Reference162 articles.

1. CH Bond Functionalization: Emerging Synthetic Tools for Natural Products and Pharmaceuticals

2. C–H bond activation enables the rapid construction and late-stage diversification of functional molecules

3. Palladium-Catalyzed Transformations of Alkyl C–H Bonds

4. Advancing the Logic of Chemical Synthesis: C−H Activation as Strategic and Tactical Disconnections for C−C Bond Construction

5. Arene diversification through distal C(sp 2 )−H functionalization

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