Unpicking the Cause of Stereoselectivity in Actinorhodin Ketoreductase Variants with Atomistic Simulations
Author:
Affiliation:
1. School of Biochemistry, University of Bristol, University Walk, Bristol, BS8 1TD, United Kingdom
2. Centre for Computational Chemistry, University of Bristol, Cantock’s Close, Bristol, BS8 1TS, United Kingdom
Funder
Biotechnology and Biological Sciences Research Council
Publisher
American Chemical Society (ACS)
Subject
Catalysis,General Chemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/acscatal.8b04846
Reference85 articles.
1. Type II polyketide synthases: gaining a deeper insight into enzymatic teamwork
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4. Structural and Biochemical Studies of the Hedamycin Type II Polyketide Ketoreductase (HedKR): Molecular Basis of Stereo- and Regiospecificities
5. Structural Analysis of Actinorhodin Polyketide Ketoreductase: Cofactor Binding and Substrate Specificity
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