Mechanistic Insights into Substrate Positioning That Distinguish Non-heme Fe(II)/α-Ketoglutarate-Dependent Halogenases and Hydroxylases-Reference-Cited by-同舟云学术

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Mechanistic Insights into Substrate Positioning That Distinguish Non-heme Fe(II)/α-Ketoglutarate-Dependent Halogenases and Hydroxylases

Published:2023-02-03 Issue:4 Volume:13 Page:2489-2501
ISSN:2155-5435
Container-title:ACS Catalysis
language:en
Short-container-title:ACS Catal.

Author:

Kastner David W.¹²^ORCID,Nandy Aditya¹³^ORCID,Mehmood Rimsha¹³,Kulik Heather J.¹³^ORCID

Affiliation:

1. Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States

2. Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States

3. Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States

Funder

Basic Energy Sciences

Division of Chemical, Bioengineering, Environmental, and Transport Systems

Publisher

American Chemical Society (ACS)

Subject

Catalysis,General Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acscatal.2c06241

Reference107 articles.

1. FIH-1: a novel protein that interacts with HIF-1α and VHL to mediate repression of HIF-1 transcriptional activity

2. Chloride Supports O2 Activation in the D201G Facial Triad Variant of Factor-Inhibiting Hypoxia Inducible Factor, an α-Ketoglutarate Dependent Oxygenase

3. AlkB-mediated oxidative demethylation reverses DNA damage in Escherichia coli

4. Oxidative demethylation by Escherichia coli AlkB directly reverts DNA base damage

5. Iron-catalysed oxidation intermediates captured in a DNA repair dioxygenase

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1. Optimized Substrate Positioning Enables Switches in the C–H Cleavage Site and Reaction Outcome in the Hydroxylation–Epoxidation Sequence Catalyzed by Hyoscyamine 6β-Hydroxylase;Journal of the American Chemical Society;2024-08-22

2. Controllable Multihalogenation of a Non-native Substrate by the SyrB2 Iron Halogenase;ACS Catalysis;2024-08-19

3. Coordination dynamics of iron enables the selective C–N coupling but bypasses unwanted C–H hydroxylation in Fe(II)/α-ketoglutarate- dependent non-heme enzymes;Chinese Journal of Catalysis;2024-07

4. Discovery and substrate specificity engineering of nucleotide halogenases;Nature Communications;2024-06-19

5. Conformational Isomerization of the Fe(III)–OH Species Enables Selective Halogenation in Carrier-Protein-Independent Halogenase BesD and Hydroxylase-Evolved Halogenase;ACS Catalysis;2024-06-05

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