Elucidation of the α-Ketoamide Inhibition Mechanism: Revealing the Critical Role of the Electrostatic Reorganization Effect of Asp17 in the Active Site of the 20S Proteasome-Reference-Cited by-同舟云学术

Elucidation of the α-Ketoamide Inhibition Mechanism: Revealing the Critical Role of the Electrostatic Reorganization Effect of Asp17 in the Active Site of the 20S Proteasome

Published:2023-10-25 Issue:21 Volume:13 Page:14368-14376
ISSN:2155-5435
Container-title:ACS Catalysis
language:en
Short-container-title:ACS Catal.

Author:

Zhou Jiao¹^ORCID,Sang Xiaohong¹^ORCID,Wang Juan²,Xu Yan¹³,An Jing³,Chu Zhen Tao⁴,Saha Arjun⁵^ORCID,Warshel Arieh⁴^ORCID,Huang Ziwei¹²³

Affiliation:

1. Ciechanover Institute of Precision and Regenerative Medicine, School of Medicine, Chinese University of Hong Kong, Shenzhen 518172, China

2. School of Life Sciences, Tsinghua University, Beijing 100084, China

3. Department of Medicine, Division of Infectious Diseases and Global Public Health, School of Medicine, University of California at San Diego, La Jolla, California92037, United States

4. Department of Chemistry, University of Southern California, Los Angeles, California 90089, United States

5. Department of Chemistry & Biochemistry, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin 53213, United States

Funder

University of Southern California

National Institute of General Medical Sciences

Ganghong Young Scholar Development Fund

Shenzhen-Hong Kong Cooperation Zone for Technology and Innovation

Publisher

American Chemical Society (ACS)

Subject

Catalysis,General Chemistry

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