Design and Synthesis of a Fluoroindolocarbazole Series as Selective Topoisomerase I Active Agents. Discovery of Water-Soluble 3,9-Difluoro-12,13-dihydro-13-[6-amino-β- d-glucopyranosyl]-5H,13H-benzo[b]- thienyl[2,3-a]pyrrolo[3,4-c]carbazole- 5,7(6H)-dione (BMS-251873) with Curative Antitumor Activity against Prostate Carcinoma Xenograft Tumor Model-Reference-Cited by-同舟云学术

Design and Synthesis of a Fluoroindolocarbazole Series as Selective Topoisomerase I Active Agents. Discovery of Water-Soluble 3,9-Difluoro-12,13-dihydro-13-[6-amino-β- d-glucopyranosyl]-5H,13H-benzo[b]- thienyl[2,3-a]pyrrolo[3,4-c]carbazole- 5,7(6H)-dione (BMS-251873) with Curative Antitumor Activity against Prostate Carcinoma Xenograft Tumor Model

Published:2004-02-20 Issue:7 Volume:47 Page:1609-1612
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Balasubramanian Balu N.¹,St. Laurent Denis R.¹,Saulnier Mark G.¹,Long Byron H.¹,Bachand Carol¹,Beaulieu Francis¹,Clarke Wendy¹,Deshpande Milind¹,Eummer Jeffrey¹,Fairchild Craig R.¹,Frennesson David B.¹,Kramer Robert¹,Lee Frank Y.¹,Mahler Mikael¹,Martel Alain¹,Naidu B. Narasimhulu¹,Rose William C.¹,Russell John¹,Ruediger Edward¹,Solomon Carola¹,Stoffan Karen M.¹,Wong Henry¹,Zimmermann Kurt¹,Vyas Dolatrai M.¹

Affiliation:

1. The Bristol-Myers Squibb Pharmaceutical Research Institute, 5 Research Parkway, Wallingford Connecticut 06492, P.O. Box 4000, Princeton, New Jersey 08543, and Candiac, Montreal, Canada

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm034197s

Reference16 articles.

1. Topoisomerase I Poisons and Suppressors as Anticancer Drugs

2. Experimental antitumor activity and pharmacokinetics of the camptothecin analog irinotecan (CPT-11) in mice

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