Significantly Different Covalent Binding of Oxidative Metabolites, Acyl Glucuronides, and S-Acyl CoA Conjugates Formed from Xenobiotic Carboxylic Acids in Human Liver Microsomes-Reference-Cited by-同舟云学术

Significantly Different Covalent Binding of Oxidative Metabolites, Acyl Glucuronides, and S-Acyl CoA Conjugates Formed from Xenobiotic Carboxylic Acids in Human Liver Microsomes

Published:2015-04-08 Issue:5 Volume:28 Page:886-896
ISSN:0893-228X
Container-title:Chemical Research in Toxicology
language:en
Short-container-title:Chem. Res. Toxicol.

Author:

Darnell Malin¹,Breitholtz Katarina¹,Isin Emre M.¹,Jurva Ulrik¹,Weidolf Lars¹

Affiliation:

1. CVMD iMed DMPK, ‡Drug Safety & Metabolism, AstraZeneca R&D Mölndal, 431 83 Mölndal, Sweden

Publisher

American Chemical Society (ACS)

Subject

Toxicology,General Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/tx500514z

Reference49 articles.

1. Immune mechanisms in tienilic acid associated hepatotoxicity.

2. Specificity of in vitro Covalent Binding of Tienilic Acid Metabolites to Human Liver Microsomes in Relationship to the Type of Hepatotoxicity: Comparison with Two Directly Hepatotoxic Drugs

3. Disposition and irreversible plasma protein binding of tolmetin in humans

4. Enantioselective Covalent Binding of 2-Phenylpropionic Acid to Protein in Vitro in Rat Hepatocytes

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