N-Pyridyl and Pyrimidine Benzamides as KCNQ2/Q3 Potassium Channel Openers for the Treatment of Epilepsy-Reference-Cited by-同舟云学术

N-Pyridyl and Pyrimidine Benzamides as KCNQ2/Q3 Potassium Channel Openers for the Treatment of Epilepsy

Published:2011-04-08 Issue:6 Volume:2 Page:481-484
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Amato George¹,Roeloffs Rosemarie¹,Rigdon Greg C.¹,Antonio Brett¹,Mersch Theresa¹,McNaughton-Smith Grant¹,Wickenden Alan D.¹,Fritch Paul¹,Suto Mark J.¹

Affiliation:

1. Departments of †Chemistry, ‡Pharmacology, and §Biology, Icagen Inc., 4222 Emperor Boulevard, Durham, North Carolina 27702, United States

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/ml200053x

Reference19 articles.

1. Muscarinic suppression of a novel voltage-sensitive K+ current in a vertebrate neurone

2. KCNQ2 and KCNQ3 Potassium Channel Subunits: Molecular Correlates of the M-Channel

3. A Potassium Channel Mutation in Neonatal Human Epilepsy

4. A pore mutation in a novel KQT-like potassium channel gene in an idiopathic epilepsy family

5. A novel potassium channel gene, KCNQ2, is mutated in an inherited epilepsy of newborns

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