Production of Soluble ScFvs with C-Terminal-Free Thiol for Site-Specific Conjugation or Stable Dimeric ScFvs on Demand

Author:

Albrecht Huguette1,Burke Patricia A.1,Natarajan Arutselvan1,Xiong Cheng-Yi1,Kalicinsky Mark1,DeNardo Gerald L.1,DeNardo Sally J.1

Affiliation:

1. Radiodiagnosis and Therapy, Molecular Cancer Institute, University of California Davis Medical Center, Sacramento, California 95816

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Pharmaceutical Science,Pharmacology,Biomedical Engineering,Bioengineering,Biotechnology

Reference56 articles.

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2. Juweid, M. E., Stadtmauer, E., Hajjar, G., Sharkey, R. M., Suleiman, S., Luger, S., Swayne, L. C., Alavi, A., Goldenberg, D. M. (1999) Pharmacokinetics, dosimetry and initial therapeutic results with131I- and111In-/90Y-labeled humanized LL2 anti-CD22 monoclonal antibody (MAb) in patients with relapsed/refractory non-Hodgkin's lymphoma (NHL).Clin. Cancer Res.5, 3292s−3303s.

3. Phase I/II Trial of IDEC-Y2B8 Radioimmunotherapy for Treatment of Relapsed or Refractory CD20+ B-Cell Non-Hodgkin's Lymphoma

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