1. Welsh School of Pharmacy, Cardiff University, Cardiff, CF10 3XF, Wales, United Kingdom, Cell Biology and Biophysics, EMBL-Heidelberg, 69117 Heidelberg, Germany, Institute for Chemical Research, Kyoto University, Uji, Kyoto 611-0011, Japan, and PRESTO, Japan Science and Technology Agency (JST), Kawaguchi, Saitama 332-0012, Japan