Toward an Understanding of Agonist Binding to Human Orexin-1 and Orexin-2 Receptors with G-Protein-Coupled Receptor Modeling and Site-Directed Mutagenesis-Reference-Cited by-同舟云学术

Toward an Understanding of Agonist Binding to Human Orexin-1 and Orexin-2 Receptors with G-Protein-Coupled Receptor Modeling and Site-Directed Mutagenesis

Published:2013-11-08 Issue:46 Volume:52 Page:8246-8260
ISSN:0006-2960
Container-title:Biochemistry
language:en
Short-container-title:Biochemistry

Author:

Heifetz Alexander¹,Barker Oliver¹,Morris G. Benjamin²,Law Richard J.¹,Slack Mark³,Biggin Philip C.²

Affiliation:

1. Evotec (U.K.) Ltd., 114 Innovation Drive, Milton Park, Abingdon, Oxfordshire OX14 4RZ, U.K.

2. Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, U.K.

3. Evotec AG, Manfred Eigen Campus, Essener Bogen 7, 22419 Hamburg, Germany

Funder

Biotechnology and Biological Sciences Research Council

Publisher

American Chemical Society (ACS)

Subject

Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/bi401119m

Reference87 articles.

1. Antagonism of orexin type 1 receptors in the locus coeruleus attenuates signs of naloxone-precipitated morphine withdrawal in rats

2. Hypocretin1/OrexinA-containing axons innervate locus coeruleus neurons that project to the Rat medial prefrontal cortex. Implication in the sleep-wakefulness cycle and cortical activation

3. Orexins/hypocretins and orexin receptors in apoptosis: a mini-review

4. Neuroendocrine Proopiomelanocortin Neurons Are Excited by Hypocretin/Orexin

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