Spin-Trapping of the p-Benzyne Intermediates from Ten-Membered Enediyne Calicheamicin γ1I

Author:

Usuki Toyonobu1,Nakanishi Koji1,Ellestad George A.1

Affiliation:

1. Department of Chemistry, Columbia University, New York, New York 10027

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Reference22 articles.

1. Calichemicins, a novel family of antitumor antibiotics. 1. Chemistry and partial structure of calichemicin .gamma.1I

2. Calichemicins, a novel family of antitumor antibiotics. 2. Chemistry and structure of calichemicin .gamma.1I

3. Calicheamicins, a novel family of antitumor antibiotics. 4. Structure elucidation of calicheamicins .beta.1Br, .gamma.1Br, .alpha.2I, .alpha.3I, .beta.1I, .gamma.1I, and .delta.1I

4. Lee, M. D.; Durr, F. E.; Hinman, L. M.; Hamann, P. R.; Ellestad, G. A. InAdvances in Medicinal Chemistry; Maryanoff, B. E., Maryanoff, C. A., Eds.; JAI Press:  New York, 1993; Vol. 2, p 31.

5. For reviews on enediyne natural products:  (a) Xi, Z.; Goldberg, I. H. InComprehensive Natural Products Chemistry; Barton, D. H. R., Nakanishi, K., Eds.; Elsevier:  New York, 1999; Vol. 7, p 553. (b) Galm, U.; Hager, M. H.; Van Lanen, S. G.; Ju, J.; Thorson, J. S.; Shen, B.Chem. Rev.2005,105, 739. For a recent review of calicheamicin:  (c) Thorson, J. S.; Sievers, E. L.; Ahlert, J.; Shepard, E.; Whitwam, R. E.; Onwueme, K. C.; Ruppen, M.Curr.Pharm. Des.2000,6, 1841.

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