2-(2-Oxo-1,4-dihydro-2H-quinazolin-3-yl)- and 2-(2,2-Dioxo-1,4-dihydro-2H-2λ6-benzo[1,2,6]thiadiazin-3-yl)-N-hydroxy-acetamides as Potent and Selective Peptide Deformylase Inhibitors
Author:
Affiliation:
1. Discovery Chemistry, F. Hoffmann-La Roche Ltd., CH-4070 Basle, Switzerland
Publisher
American Chemical Society (ACS)
Subject
Drug Discovery,Molecular Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/jm000352g
Reference39 articles.
1. Structure-function relationships within the peptide deformylase family. Evidence for a conserved architecture of the active site involving three conserved motifs and a metal ion 1 1Edited by F. E. Cohen
2. Genetic characterization of polypeptide deformylase, a distinctive enzyme of eubacterial translation.
3. A survey of polypeptide deformylase function throughout the eubacterial lineage
4. Identification of eukaryotic peptide deformylases reveals universality of N-terminal protein processing mechanisms
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