Structural Optimization of 2,5-Thiophene Amides as Highly Potent and Selective 17β-Hydroxysteroid Dehydrogenase Type 2 Inhibitors for the Treatment of Osteoporosis-Reference-Cited by-同舟云学术

Structural Optimization of 2,5-Thiophene Amides as Highly Potent and Selective 17β-Hydroxysteroid Dehydrogenase Type 2 Inhibitors for the Treatment of Osteoporosis

Published:2012-12-19 Issue:1 Volume:56 Page:167-181
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Marchais-Oberwinkler Sandrine¹,Xu Kuiying¹,Wetzel Marie¹,Perspicace Enrico¹,Negri Matthias²,Meyer Arne³,Odermatt Alex³,Möller Gabriele⁴,Adamski Jerzy⁴⁵,Hartmann Rolf W.¹²

Affiliation:

1. Pharmaceutical and Medicinal Chemistry, Saarland University, D-66041 Saarbrücken, Germany

2. Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Campus C23, D-66123 Saarbrücken, Germany

3. Division of Molecular and Systems Toxicology, Department of Pharmaceutical Sciences, University of Basel, Klingelbergstraße 50, CH-4056 Basel, Switzerland

4. Genome Analysis Center, Institute of Experimental Genetic, Helmholtz Zentrum München, D-85764 Neuherberg, Germany

5. Lehrstuhl für Experimentelle Genetik, Technische Universität München, D-85350 Freising-Weihenstephan, Germany

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm3014053

Reference65 articles.

1. Expression cloning and characterization of human 17 beta-hydroxysteroid dehydrogenase type 2, a microsomal enzyme possessing 20 alpha-hydroxysteroid dehydrogenase activity

2. Tissue culture models for studies of hormone and vitamin action in bone cells

3. Androgens and bone

4. Androgens and Bone

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