Pyridyl Benzamides as a Novel Class of Potent Inhibitors for the Kinetoplastid Trypanosoma brucei

Author:

Ferrins Lori,Gazdik Michelle12,Rahmani Raphaël,Varghese Swapna1,Sykes Melissa L.3,Jones Amy J.3,Avery Vicky M.3,White Karen L.,Ryan Eileen,Charman Susan A.,Kaiser Marcel45,Bergström Christel A. S.6,Baell Jonathan B.27

Affiliation:

1. Department of Chemistry, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Victoria 3086, Australia

2. The Walter and Eliza Hall Institute, 1G Royal Parade, Parkville, Victoria 3052, Australia

3. Eskitis Institute for Drug Discovery, Griffith University, Brisbane Innovation Park, Don Young Road, Nathan, Queensland 4111, Australia

4. Swiss Tropical and Public Health Institute, Socinstrasse 57, Basel, 4051, Switzerland

5. University of Basel, Petersplatz 1, Basel, 4003, Switzerland

6. Department of Pharmacy, Uppsala University, Biomedical Center P.O. Box 580, SE-751 23 Uppsala, Sweden

7. Department of Medical Biology, University of Melbourne, Parkville, Victoria 3010, Australia

Funder

National Health and Medical Research Council

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Reference41 articles.

1. WHO. Control andsurveillance of human African trypanosomiasis. http://apps.who.int/iris/bitstream/10665/95732/1/9789241209847_eng.pdf(accessed, 10th January, 2014) .

2. Human African trypanosomiasis

3. WHO.Drugs. http://www.who.int/trypanosomiasis_african/drugs/en/index.html(accessed, July 27, 2012) .

4. Transporters in African trypanosomes: role in drug action and resistance

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