A New Strategy toward the Total Synthesis of Stachyflin, A Potent Anti-Influenza A Virus Agent: Concise Route to the Tetracyclic Core Structure-Reference-Cited by-同舟云学术

A New Strategy toward the Total Synthesis of Stachyflin, A Potent Anti-Influenza A Virus Agent: Concise Route to the Tetracyclic Core Structure

Published:2002-11-16 Issue:25 Volume:4 Page:4483-4486
ISSN:1523-7060
Container-title:Organic Letters
language:en
Short-container-title:Org. Lett.

Author:

Nakatani Mari¹,Nakamura Masahiko¹,Suzuki Akiyuki¹,Inoue Munenori¹,Katoh Tadashi¹

Affiliation:

1. Sagami Chemical Research Center, Hayakawa 2743-1, Ayase, Kanagawa 252-1193, Japan

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/ol0271032

Reference19 articles.

1. (a) Kamigauchi, T.; Fujiwara, T.; Tani, H.; Kawamura, Y.; Horibe, I (Shionogi & Co., Ltd, Japan) PCT WO 9711947 A1, April 3, 1997.

2. Stachyflin and Acetylstachyflin, Novel Anti-influenza A Virus Substances, Produced by Stachybotrys sp. RF-7260. I. Isolation, Structure Elucidation and Biological Activities.

3. Stachyflin and Acetylstachyflin, Novel Anti-influenza A Virus Substances, Produced by Stachybotrys sp. RF-7260. II. Synthesis and Preliminary Structure-Activity Relationships of Stachyflin Derivatives.

4. It is reported that the anti-influenza A virus activity of stachyflin (1) is 1760 times more active than that of amantadine (IC50= 5.3 μM) and is 250 times more active than that of zanamivir (IC50= 0.75 μM); see ref 1b.

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