A Systematic Evaluation of the Bleomycin A2 l-Threonine Side Chain: Its Role in Preorganization of a Compact Conformation Implicated in Sequence-Selective DNA Cleavage-Reference-Cited by-同舟云学术

A Systematic Evaluation of the Bleomycin A2 l-Threonine Side Chain: Its Role in Preorganization of a Compact Conformation Implicated in Sequence-Selective DNA Cleavage

Published:1998-08-28 Issue:36 Volume:120 Page:9139-9148
ISSN:0002-7863
Container-title:Journal of the American Chemical Society
language:en
Short-container-title:J. Am. Chem. Soc.

Author:

Boger Dale L.¹,Ramsey Timothy M.¹,Cai Hui¹,Hoehn Silvia T.¹,Stubbe JoAnne¹

Affiliation:

1. Contribution from the Department of Chemistry and the Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, and Departments of Chemistry and Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139

Publisher

American Chemical Society (ACS)

Subject

Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis

Link

https://pubs.acs.org/doi/pdf/10.1021/ja9816638

Reference64 articles.

1. Kane, S. A.; Hecht, S. M. InProgress in Nucleic Acids Research and Molecular Biology; Cohn, W. E., Moldave, K., Eds.; Academic: San Diego, 1994; Vol. 49, p 313.

2. Ohno, M.; Otsuka, M. InRecent Progress in the Chemical Synthesis of Antibiotics; Lukacs, G., Ohno, M., Eds.; Springer-Verlag: New York, 1990; p 387.

3. Free-radical mechanisms involved in the formation of sequence-dependent bistranded DNA lesions by the antitumor antibiotics bleomycin, neocarzinostatin, and calicheamicin

4. The role of redox-active metals in the mechanism of action of bleomycin

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