1. Ottawa Institute of Systems Biology, Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, and Department of Chemistry, University of Ottawa, 451 Smyth Road, Ottawa, Ontario, Canada K1H 8M5, and Key Laboratory of Separation Science for Analytical Chemistry and National Chromatographic R&A Center, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian, China 116023