Fluorocyclines. 1. 7-Fluoro-9-pyrrolidinoacetamido-6-demethyl-6-deoxytetracycline: A Potent, Broad Spectrum Antibacterial Agent-Reference-Cited by-同舟云学术

Fluorocyclines. 1. 7-Fluoro-9-pyrrolidinoacetamido-6-demethyl-6-deoxytetracycline: A Potent, Broad Spectrum Antibacterial Agent

Published:2012-01-04 Issue:2 Volume:55 Page:597-605
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Xiao Xiao-Yi¹,Hunt Diana K.¹,Zhou Jingye¹,Clark Roger B.¹,Dunwoody Nick¹,Fyfe Corey¹,Grossman Trudy H.¹,O’Brien William J.¹,Plamondon Louis¹,Rönn Magnus¹,Sun Cuixiang¹,Zhang Wu-Yan¹,Sutcliffe Joyce A.¹

Affiliation:

1. Discovery Chemistry, ‡Microbiology, and §Process Chemistry R&D, Tetraphase Pharmaceuticals, 480 Arsenal Street, Watertown, Massachusetts 02472, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm201465w

Reference45 articles.

1. Hunt, D. K., Xiao, X.Y, Clark, R. B., O’Brien, W. J., Fyfe, C., Grossman, T. H., Sutcliffe, J. A., and Plamondon, L.TP-434 is a Novel Broad-spectrum Fluorocycline. Presented at the50th Interscience Conference on Antimicrobial Agents and Chemotherapy Conference,Boston, MA,September 12–15, 2010, posterF1–2157.

2. Conover, L H.Discovery of Drugs from Microbiological Sources.Drug Discovery, Science and Development in a Changing Society:American Chemical Society:Washington, DC, 1971; Vol.108. pp33–80.

3. Tetracycline Antibiotics: Mode of Action, Applications, Molecular Biology, and Epidemiology of Bacterial Resistance

4. The growing burden of antimicrobial resistance

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