Syntheses, Biological Evaluation, and Molecular Modeling of 18F-Labeled 4-Anilidopiperidines as μ-Opioid Receptor Imaging Agents-Reference-Cited by-同舟云学术

Syntheses, Biological Evaluation, and Molecular Modeling of 18F-Labeled 4-Anilidopiperidines as μ-Opioid Receptor Imaging Agents

Published:2005-11-03 Issue:24 Volume:48 Page:7720-7732
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Henriksen Gjermund¹,Platzer Stefan¹,Marton János¹,Hauser Andrea¹,Berthele Achim¹,Schwaiger Markus¹,Marinelli Luciana¹,Lavecchia Antonio¹,Novellino Ettore¹,Wester Hans-Jürgen¹

Affiliation:

1. Department of Nuclear Medicine, Klinikum rechts der Isar, Technische Universität München, Ismaninger Strasse 22, D-81675 Munich, Germany, Department of Neurology, Klinikum rechts der Isar, Technische Universität München, Möhlstrasse 28, D-81675 Munich, Germany, ABX Advanced Biochemical Compounds GmbH, Heinrich-Glaeser-Strasse 10-14, D-01454 Radeberg, Germany, and Dipartimento di Chimica Farmaceutica e Tossicologica, Università di Napoli “Federico II”, Via D. Montesano, 49-80131 Napoli, Italy

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm0507274

Reference67 articles.

1. Loss of morphine-induced analgesia, reward effect and withdrawal symptoms in mice lacking the µ-opioid-receptor gene

2. Absence of opioid stress-induced analgesia in mice lacking beta-endorphin by site-directed mutagenesis.

3. Regional Mu Opioid Receptor Regulation of Sensory and Affective Dimensions of Pain

4. Pain activation of human supraspinal opioid pathways as demonstrated by [11C]-carfentanil and positron emission tomography (PET)

5. Increased mu opioid receptor binding detected by PET in cocaine–dependent men is associated with cocaine craving

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