Quinazolin-4-one α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptor Antagonists: Structure−Activity Relationship of the C-2 Side Chain Tether-Reference-Cited by-同舟云学术

Quinazolin-4-one α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptor Antagonists: Structure−Activity Relationship of the C-2 Side Chain Tether

Published:2001-04-25 Issue:11 Volume:44 Page:1710-1717
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Chenard Bertrand L.¹,Welch Willard M.¹,Blake James F.¹,Butler Todd W.¹,Reinhold Anthony¹,Ewing Frank E.¹,Menniti Frank S.¹,Pagnozzi Martin J.¹

Affiliation:

1. Global Research and Development, Groton Laboratories, Pfizer Inc., Groton, Connecticut 06340

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm000522p

Reference12 articles.

1. AMPA receptor agonists, antagonists and modulators: their potential for clinical utility

2. Atropisomeric quinazolin-4-one derivatives are potent noncompetitive α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonists

3. Methaqualone derivatives are potent noncompetitive AMPA receptor antagonists

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