Design, Synthesis, and Evaluation of 3,4-Dihydro-2H-[1,4]diazepino[6,7,1-hi]indol-1-ones as Inhibitors of Poly(ADP-Ribose) Polymerase-Reference-Cited by-同舟云学术

Design, Synthesis, and Evaluation of 3,4-Dihydro-2H-[1,4]diazepino[6,7,1-hi]indol-1-ones as Inhibitors of Poly(ADP-Ribose) Polymerase

Published:2004-09-29 Issue:22 Volume:47 Page:5467-5481
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Tikhe Jayashree G.¹,Webber Stephen E.¹,Hostomsky Zdenek¹,Maegley Karen A.¹,Ekkers Anne¹,Li Jianke¹,Yu Xiao-Hong¹,Almassy Robert J.¹,Kumpf Robert A.¹,Boritzki Theodore J.¹,Zhang Cathy¹,Calabrese Chris R.¹,Curtin Nicola J.¹,Kyle Suzanne¹,Thomas Huw D.¹,Wang Lan-Zhen¹,Calvert A. Hilary¹,Golding Bernard T.¹,Griffin Roger J.¹,Newell David R.¹

Affiliation:

1. Pfizer Global R&DLa Jolla Laboratories, 10770 Science Center Drive, San Diego, California 92121, Anadys Pharmaceuticals, 3115 Merryfield Row, San Diego, California 92121, Quorex Pharmaceuticals, 1890 Rutherford Road, #200, Carlsbad, California 92008, and University of Newcastle, Newcastle upon Tyne NE2 4HH, United Kingdom

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm030513r

Reference50 articles.

1. From DNA Damage and Stress Signaling to Cell Death: PolyADP-Ribosylation Reactions; de Murcia, G., Shall, S., Eds; Oxford University Press: Oxford, United Kingdom, 2000; and references therein.

2. A Human Poly(ADP-ribose) Polymerase Gene Family (ADPRTL): cDNA Cloning of Two Novel Poly(ADP-ribose) Polymerase Homologues

3. The 193-Kd Vault Protein, Vparp, Is a Novel Poly(Adp-Ribose) Polymerase

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