1. Department of Biomedical Engineering, Duke University, 101 Science Drive, Durham, North Carolina 27708-0281, United States, St. Jude Medical, 11175 Cicero Drive, Suite 675, Alpharetta, Georgia 30022, United States, and Department of Pharmacology and Pharmaceutical Sciences, University of Southern California, 1985 Zonal Avenue, Los Angeles, California 90033-9121, United States