Synthesis and Pharmacology of 6-Substituted Benztropines: Discovery of Novel Dopamine Uptake Inhibitors Possessing Low Binding Affinity to the Dopamine Transporter-Reference-Cited by-同舟云学术

Synthesis and Pharmacology of 6-Substituted Benztropines: Discovery of Novel Dopamine Uptake Inhibitors Possessing Low Binding Affinity to the Dopamine Transporter

Published:2005-04-05 Issue:9 Volume:48 Page:3337-3343
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Simoni Daniele¹,Rossi Marcello¹,Bertolasi Valerio¹,Roberti Marinella¹,Pizzirani Daniela¹,Rondanin Riccardo¹,Baruchello Riccardo¹,Invidiata Francesco Paolo¹,Tolomeo Manlio¹,Grimaudo Stefania¹,Merighi Stefania¹,Varani Katia¹,Gessi Stefania¹,Borea Pier Andrea¹,Marino Silvia¹,Cavallini Sabrina¹,Bianchi Clementina¹,Siniscalchi Anna¹

Affiliation:

1. Dipartimento di Scienze Farmaceutiche, Università di Ferrara, Via Fossato di Mortara 17-19, 44100 Ferrara, Italy, Dipartimento di Chimica, Università di Ferrara, Dipartimento di Scienze Farmaceutiche, Università di Bologna, Dipartimento Farmacochimico Tossicologico e Biologico, Università di Palermo, Divisione di Ematologia e Servizio A.I.D.S., Policlinico, Università di Palermo, Italy, and Dipartimento di Medicina Clinica e Sperimentale, Sezione di Farmacologia, Università di Ferrara, Italy

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm0490235

Reference24 articles.

1. The dopamine hypothesis of the reinforcing properties of cocaine

2. Molecular and regional targets of cocaine in primate brain: liberation from prosaic views

3. Probes for the dopamine transporter: New leads toward a cocaine-abuse therapeutic?A focus on analogues of benztropine and rimcazole

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